2011 american society of clinical oncology.
نویسنده
چکیده
dacarbazine/placebo (HR = 0.76 [0.63–0.93]; P = 0.006). Rates of adverse events (AEs) were higher with ipilimu mab/dacarbazine and were consistent with those found in previous studies. Most AEs were immune-based and were responsive to dose interruptions or discontinuations, corticosteroids, or other immunosuppressants. Dr. Wolchok noted that although rates of diarrhea (overall, 35.4%; grade 3–4, 4%) and colitis rates (4.5%; grade 3–4, 2%) were lower than in phase 2 trials, rates for elevated aspartate transaminase (AST, 29.1%; grade 3–4, 18.2%) and alanine transaminase (ALT, 33.2%; grade 3–4, 21.9%) were higher. Dr. Wolchok concluded, “This is the second randomized ipilimumab phase 3 trial to show significant survival improvement in metastatic melanoma.”
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ورودعنوان ژورنال:
- P & T : a peer-reviewed journal for formulary management
دوره 36 8 شماره
صفحات -
تاریخ انتشار 2011