2011 american society of clinical oncology.

نویسنده

  • Walter Alexander
چکیده

dacarbazine/placebo (HR = 0.76 [0.63–0.93]; P = 0.006). Rates of adverse events (AEs) were higher with ipilimu mab/dacarbazine and were consistent with those found in previous studies. Most AEs were immune-based and were responsive to dose interruptions or discontinuations, corticosteroids, or other immunosuppressants. Dr. Wolchok noted that although rates of diarrhea (overall, 35.4%; grade 3–4, 4%) and colitis rates (4.5%; grade 3–4, 2%) were lower than in phase 2 trials, rates for elevated aspartate transaminase (AST, 29.1%; grade 3–4, 18.2%) and alanine transaminase (ALT, 33.2%; grade 3–4, 21.9%) were higher. Dr. Wolchok concluded, “This is the second randomized ipilimumab phase 3 trial to show significant survival improvement in metastatic melanoma.”

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Prostate cancer: evolution or revolution?

In this issue of Journal of Clinical Oncology, we present a special series on prostate cancer that illustrates how our understanding of the biology and therapy of this disease has changed over the last few years. This series comes on the heels of the 2011 Genitourinary Cancers Symposium (held February 17 to 19, 2011, in Orlando, FL), jointly sponsored by the American Society of Clinical Oncolog...

متن کامل

Future of treatment for low-risk prostate cancer: for all, for some, or for none?

ASCO’s conflict of interest policy, please refer to the Author Disclosure Declaration and the Disclosures of Potential Conflicts of Interest section in Information for Contributors. Employment or Leadership Position: None Consultant or Advisory Role: Alberto F. Sobrero, Bayer (C), Amgen (C), Roche (C), Merck Serono (C), Astra Zeneca (C), sanofi-aventis (C) Stock Ownership: None Honoraria: Alber...

متن کامل

ASCO-CAP guidelines for breast predictive factor testing: an update.

This brief report compares and contrasts the American Society of Clinical Oncology/College of American Pathologists guidelines for breast cancer predictive factor testing including the American Society of Clinical Oncology/College of American Pathologists human epidermal growth factor receptor, type 2, erbB2 Guideline published in 2007 and the recently published Guideline for Estrogen Receptor ...

متن کامل

Personalized medicine in a phase I clinical trials program: The M. D. Anderson Cancer Center Initiative.

CRA2500 The full, final text of this abstract will be available in Part II of the 2011 Annual Meeting Proceedings, distributed onsite at the Meeting on June 4, 2011, and as a supplement to the June 20, 2011, issue of Journal of Clinical Oncology.

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • P & T : a peer-reviewed journal for formulary management

دوره 36 8  شماره 

صفحات  -

تاریخ انتشار 2011